Endocrine Abstracts

Background: Kisspeptin is a neuropeptide central to the regulation of gonadotrophin secretion but recent studies have suggested more diverse roles in human physiology. Kisspeptin is a potent inhibitor of tumour metastasis and plays a role in placentation, both processes involving angiogenesis. In addition, Kisspeptin and its receptor, GPR54, have been identified in human blood vessels including aorta, coronary artery and umbilical vein, where they mediate vasoconstriction. We,...